TUMBLER

ANTIBODY ENGINEERING TECHNOLOGY

Antibodies are complicated. Old methods for antibody engineering relied on time consuming mutational scans. Our paradigm-shifting Tumbler Technology provides a library-based repertoire engineering method for rapidly generating billions of versions of an input antibody in order to affinity mature, thermostabilize, deimmunize, species-cross react, biochemical liability remove, humanize, pH sensitize, BBB passage, and otherwise engineer an input client antibody. Tumbler works by recombining naturally antibody genetic elements from over a hundred subjects in elegantly controlled proportions across your starting antibody. The resulting Tumbler library explores all the variations that the human body could have, and it is able to to it all in parallel with a diversity unmatched by any other technology, allowing us to select across a vast local search space of human and non-immunogenic variants for biosuperiors with remarkable new characteristics. Artificial-intelligence is used to analyze the outputs of these selections to further optimize the perfect final lead (see Glanville, Nature 2017). Harness humanity and engineer your antibody with Tumbler today!

EXPLORE THE AFFINITY MATURATION

of fully human antibodies

TUMBLER

TECHNOLOGY

  • Affinity

  • Stability

  • Humanness

  • Polyreactivity

  • pH sensitivity

  • Dual-specificity

  • Multi-species cross-reactivity

(415) 489-0246

201 Gateway Blvd, Floor 1

 South San Francisco, CA 94080, USA