THOUSANDS of hits against ANY ANTIGEN with a COMPUTATIONALLY OPTIMIZED REPERTOIRE
A therapeutic-ready monoclonal antibody can take years to be discovered and subsequently engineered. Our SuperHuman-2.0 antibody library was computationally optimized for both sequence diversity and engineering fitness through the analysis of thousands of human antibody repertoires and all known monoclonal therapeutics in human phase trials.
The resulting library is over 100x more diverse than any previous library. This unprecedented diversity has resulted in a unique engineering opportunity: a library that generates over 5000 unique hits against every one of the antigens in our pipeline. Given the number of hits, this library can be panned under normally impossible aggressive conditions, recovering hundreds of picomolar binders, saturating coverage of hits against every epitope, and isolating multi-species cross-reactive members against target homologs without additional engineering.
SuperHuman applies a 6-fold analysis to identify a final collection of optimal VH and VL scaffolds as and provides 100% human CDR diversity and 100% germline frameworks. The technology prides itself with unbelievable speed, rapidly discovering swarms of unique antibodies against any target of interest in under 12 weeks. Explore a SuperHuman partnership with us here.