SUPERHUMAN PLATFORM LICENSE AGREEMENT

Distributed Bio has transferred and licensed its proprietary SuperHuman 2.0 antibody discovery platform to Pfizer, for the identification of novel antibodies for use as therapeutic targets. Specifically, Pfizer will use the library to perform screening activities against Pfizer-selected targets. Pfizer has also secured access to continued improvements to the SuperHuman 2.0. This is Distributed Bio Inc.’s ninth SuperHuman 2.0 platform transfer.

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"The SuperHuman Platform represents the culmination of a decade of our research in computational library design"...see press release

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PARTNERSHIP ON ANTIBODY THERAPEUTIC DESIGN PLATFORM

Distributed Bio will collaborate with Twist Biosciences to offer therapeutic antibody design and optimization services, as well as an exclusive Gprotein coupled Receptor (GPCR) targeting library, for Twist Bioscience customers. Distributed Bio will develop and supply to Twist Biosciences a custom software solution for optimized antibody design that will integrate into Twist Bioscience’s eCommerce platform.

“Distributed Bio is singularly qualified, through their depth and breadth of experience designing antibodies based on the natural human repertoire, to develop customized software for our customers”...see press release

SUPERHUMAN PLATFORM TRANSFER

Distributed Bio will transfer and license its proprietary SuperHuman 2.0 antibody discovery platform to Boehringer Ingelheim who has also secured access to continued improvements to the SuperHuman Platform. Boehringer Ingelheim will use the platform for accelerating biotherapeutics discovery across therapeutic areas.

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"The result is a library of 76 billion antibodies that contains over 5,000 hits against any antigen, including hundreds of picomolar binders, all thermostable, non-immunogenic, pre-screened by human blood and therapeutically developed in advance to avoid engineering delays downstream"....see press release

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MULTI-TARGET COLLABORATION

Distributed Bio will screen its proprietary SuperHuman antibody platform to discover therapeutic ready pre-optimized antibodies against multiple Pandion targets. Pandion will have the right to develop and commercialize therapeutic programs resulting from the collaboration. Pandion will also directly license multiple lead antibodies from Distributed Bio and may internalize the SuperHuman Platform.

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"We’re delighted to be working with the most innovative company in antibody discovery,"...see press release

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SUPERHUMAN PLATFORM TRANSFER

Kadmon will license the Distributed Bio SuperHuman platform for accelerating the discovery of antibody based drugs. Kadmon has also secured access to continued improvements to the SuperHuman Platform.

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"This is an order of magnitude more molecules than can be generated by other technologies, and will enable our partners at Kadmon to search for ultra-high affinity, species-cross reactive and exquisitely specific therapeutic antibodies at unprecedented speeds and with the confidence that their molecules will be best in class every time."...see press release

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GILES DAY

COO

Director of Contract Research

SARAH IVES